Evaluation of HPV Infection and Smoking Status Impacts on Cell Proliferation in Epithelial Layers of Cervical Neoplasia

@inproceedings{Guillaud2014EvaluationOH,
  title={Evaluation of HPV Infection and Smoking Status Impacts on Cell Proliferation in Epithelial Layers of Cervical Neoplasia},
  author={Martial Guillaud and Timon Paul Hermus Buys and Anita Carraro and Jagoda Korbelik and Michele Follen and Michael E. Scheurer and Karen Adler Storthz and Dirk J T Van Niekerk and Calum E Macaulay},
  booktitle={PloS one},
  year={2014}
}
Accurate cervical intra-epithelial neoplasia (CIN) lesion grading is needed for effective patient management. We applied computer-assisted scanning and analytic approaches to immuno-stained CIN lesion sections to more accurately delineate disease states and decipher cell proliferation impacts from HPV and smoking within individual epithelial layers. A patient cohort undergoing cervical screening was identified (n = 196) and biopsies of varying disease grades and with intact basement membranes… CONTINUE READING
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