Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types.

@article{Fu2007EvaluationOG,
  title={Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types.},
  author={Baojin Fu and Mingzhou Guo and Shelun Wang and Domenico Campagna and Mingde Luo and James G. Herman and Christine A Iacobuzio-Donahue},
  journal={Cancer biology & therapy},
  year={2007},
  volume={6 10},
  pages={1546-52}
}
The GATA-4 and GATA-5 transcription factors are increasingly recognized as playing a role in carcinogenesis of human tumors derived of endodermal and mesodermal origin. The pancreas is derived from endodermal tissues suggesting GATA-4 and GATA-5 gene methylation may play a critical role in the biology of human pancreatic cancer as well. We investigated GATA… CONTINUE READING