Evaluation of Dose-Reduced Direct Oral Anticoagulant Therapy.

  title={Evaluation of Dose-Reduced Direct Oral Anticoagulant Therapy.},
  author={Megan E. Barra and J. Fanikos and Jean M Connors and Katelyn W Sylvester and Gregory Piazza and Samuel Z. Goldhaber},
  journal={The American journal of medicine},
  volume={129 11},
BACKGROUND Compared with vitamin K antagonists, direct-acting oral anticoagulants (DOACs) have fixed dosing, limited drug interactions, and do not require therapeutic drug level monitoring. Dose adjustments are recommended for moderate renal dysfunction, low body weight, and select drug interactions. OBJECTIVES The aim of our study is to determine if DOAC dose reductions were appropriate based on the manufacturer labeling recommendations for each agent. We also followed patients' treatment… CONTINUE READING
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Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis

  • T Van der Hulle, J Kooiman, PL Den Exter
  • J Thromb Haemost
  • 2014
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