Evaluation of Different Signal Peptides for Secretory Production of Recombinant Bovine Pancreatic Ribonuclease A in Gram Negative Bacterial System: an In silico Study

@article{Forouharmehr2017EvaluationOD,
  title={Evaluation of Different Signal Peptides for Secretory Production of Recombinant Bovine Pancreatic Ribonuclease A in Gram Negative Bacterial System: an In silico Study},
  author={Ali Forouharmehr and Mohammadreza Nassiri and Shahrokh Ghovvati and Ali Javadmanesh},
  journal={Current Proteomics},
  year={2017},
  volume={14},
  pages={24-33}
}
DOI: 10.2174/1570164614666170725144424 Abstract: Background: Prokaryotic systems such as E. coli are among the most affordable and simplest hosts which are being employed to express recombinant proteins, nevertheless without appropriate signal peptide these systems cannot be used for secretory proteins. Bovine pancreatic ribonuclease A is a protein with four disulfide bonds which might be used as an immunoenzyme for immunotherapy. Consequently, the production of this recombinant protein, using… 
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