Evaluation of DNA primase DnaG as a potential target for antibiotics.

  title={Evaluation of DNA primase DnaG as a potential target for antibiotics.},
  author={Aneta Kuron and Malgorzata Korycka-Machala and Anna M. Brzostek and Marcin Nowosielski and Aidan J. Doherty and Bozena R. Dziadek and Jaroslaw Dziadek},
  journal={Antimicrobial agents and chemotherapy},
  volume={58 3},
Mycobacteria contain genes for several DNA-dependent RNA primases, including dnaG, which encodes an essential replication enzyme that has been proposed as a target for antituberculosis compounds. An in silico analysis revealed that mycobacteria also possess archaeo-eukaryotic superfamily primases (AEPs) of unknown function. Using a homologous recombination system, we obtained direct evidence that wild-type dnaG cannot be deleted from the chromosome of Mycobacterium smegmatis without disrupting… CONTINUE READING


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