Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”

@inproceedings{Johnatty2010EvaluationOC,
  title={Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”},
  author={Sharon E. Johnatty and Jonathan Beesley and Xiao-qing Chen and Stuart Macgregor and David L Duffy and Amanda B Spurdle and Anna deFazio and Natalie Gava and Penelope M Webb and Mary Anne Rossing and Jennifer A Doherty and Marc T. Goodman and Galina Lurie and Pamela J. Thompson and Lynne Ross Wilkens and Roberta B. Ness and Kirsten B Moysich and Jenny Chang-Claude and Shan Wang-gohrke and Daniel W Cramer and Kathryn L. Terry and Susan E. Hankinson and Shelley S Tworoger and Montserrat Garc{\'i}a-Closas and Hannah Yang and Jolanta Lissowska and Stephen J. Chanock and Paul P. D. Pharoah and Honglin Song and Alice S. Whitemore and Celeste Leigh Pearce and Daniel O. Stram and Anna H Wu and Malcolm C. Pike and Simon A. Gayther and Susan J Ramus and Usha Menon and Aleksandra Gentry-Maharaj and Hoda Anton-Culver and Argyrios Ziogas and Estrid V S Hogdall and Susanne Kr{\"u}ger Kjaer and Claus K. Hogdall and Andrew Berchuck and Joellen Martha Schildkraut and Edwin S. Iversen and Patricia G. Moorman and Catherine M. Phelan and Thomas A. Sellers and Julie M Cunningham and Robert A Vierkant and David N. Rider and Ellen L. Goode and Izhak Haviv and Georgia Chenevix-Trench},
  booktitle={PLoS genetics},
  year={2010}
}
We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleotide polymorphisms (SNPs) in 173 genes involved in stromal epithelial interactions in the Ovarian Cancer Association Consortium (OCAC). In the discovery stage, cases with epithelial ovarian cancer (n=675) and controls (n=1,162) were genotyped… CONTINUE READING

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