Evaluation of CDK6 and p16/INK4a-Derived Peptides Interaction

Abstract

The goal of this work is the development of novel peptides with high efficacy of inhibiting activity of CDK6/CyclinD complex. The peptides were derived from primary sequence of P16 protein and its homologues. The interactions between CDK6 and P16/INK4a-derived peptides are studied with molecular dynamics simulation employing umbrella sampling method. The… (More)

Topics

4 Figures and Tables

Slides referencing similar topics