Evaluation of Breast Cancer Resistance Protein Function in Hepatobiliary and Renal Excretion Using PET with 11C-SC-62807

@article{Takashima2013EvaluationOB,
  title={Evaluation of Breast Cancer Resistance Protein Function in Hepatobiliary and Renal Excretion Using PET with 11C-SC-62807},
  author={T. Takashima and Chunyong Wu and Misato Takashima-Hirano and Yumiko Katayama and Y. Wada and M. Suzuki and H. Kusuhara and Y. Sugiyama and Y. Watanabe},
  journal={The Journal of Nuclear Medicine},
  year={2013},
  volume={54},
  pages={267 - 276}
}
  • T. Takashima, Chunyong Wu, +6 authors Y. Watanabe
  • Published 2013
  • Chemistry, Medicine
  • The Journal of Nuclear Medicine
  • A quantitative PET imaging method was used to assess the in vivo kinetics of hepatobiliary and renal excretion of the breast cancer resistance protein (Bcrp) substrate 11C-SC-62807 in mice. Methods: Serial abdominal PET scans were collected in wild-type and Bcrp knockout (Bcrp–/–) mice after intravenous injection of 11C-SC-62807. Venous blood samples and PET images were obtained at frequent intervals up to 30 min after radiotracer administration. Dynamic PET data were analyzed to determine the… CONTINUE READING
    32 Citations
    Influence of breast cancer resistance protein and P‐glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice
    • S. Mairinger, V. Zoufal, +8 authors O. Langer
    • Chemistry, Medicine
    • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
    • 2018
    • 1
    Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice
    • 6
    • PDF
    [¹¹C]befloxatone brain kinetics is not influenced by Bcrp function at the blood-brain barrier: a PET study using Bcrp TGEM knockout rats.
    • B. Hosten, Raphaël Boisgard, +6 authors N. Tournier
    • Chemistry, Medicine
    • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
    • 2013
    • 11
    PET Tracers To Study Clinically Relevant Hepatic Transporters.
    • 26
    MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts
    • 16
    • PDF

    References

    SHOWING 1-10 OF 32 REFERENCES
    PET Imaging–Based Evaluation of Hepatobiliary Transport in Humans with (15R)-11C-TIC-Me
    • 76
    • PDF
    Evaluation of Limiting Brain Penetration Related to P-glycoprotein and Breast Cancer Resistance Protein Using [11C]GF120918 by PET in Mice
    • 49
    • Highly Influential
    In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [(11)C]gefitinib.
    • 57
    • Highly Influential
    Positron Emission Tomography Studies Using (15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin Methyl Ester for the Evaluation of Hepatobiliary Transport
    • 43
    • PDF
    The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins.
    • 192
    Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.
    • 74
    Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans
    • 134