Evaluation of Bioadhesive Glipizide Spheres and Compacts from Spheres Prepared by Extruder/Marumerizer Technique

  title={Evaluation of Bioadhesive Glipizide Spheres and Compacts from Spheres Prepared by Extruder/Marumerizer Technique},
  author={Jos{\'e} Javier Garcia and Evone S. Ghaly},
  journal={Pharmaceutical Development and Technology},
  pages={407 - 417}
The objective of this study was to attempt to deliver glipizide from spheres and compacts containing the natural polymer Carrageenan (Gelcarin, GP 812) and prepared by extruder/marumerizer technique. A second objective was to evaluate the mucoadhesive strength of the bioadhesive spheres onto the mucus membrane of rabbit. The effects of polymer, drug level, and type of spheronizing material were evaluated. All sphere formulations were compacted into tablets using a rotary Manesty B-3B machine… 

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