Evaluation of BRCA2 in the genetic susceptibility of familial esophageal cancer

@article{Hu2004EvaluationOB,
  title={Evaluation of BRCA2 in the genetic susceptibility of familial esophageal cancer},
  author={Nan Hu and Chaoyu Wang and Xiao-you Han and Li-ji He and Ze-Zhong Tang and Carol A Giffen and Michael R. Emmert-Buck and Alisa M Goldstein and Philip R. Taylor},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={852-858}
}
Previous studies of esophageal squamous cell carcinoma (ESCC) have shown a high frequency of allelic loss on chromosome 13q, infrequent somatic mutations in BRCA2, and a suggested association between a positive family history (FH+) of upper gastrointestinal cancer and germline BRCA2 mutations. In all, 70 ESCC patients (44 FH+ and 26 FH−) were examined by direct full sequencing of germline DNA for BRCA2 mutations. In addition, 28 family members of three of these patients and 232 unrelated… CONTINUE READING

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