Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair.

Abstract

Large, osseous, segmental defects heal poorly. Muscle has a propensity to form bone when exposed to an osteogenic stimulus such as that provided by transfer and expression of cDNA encoding bone morphogenetic protein-2 (BMP-2). The present study evaluated the ability of genetically modified, autologous muscle to heal large cranial defects in rats. Autologous… (More)
DOI: 10.1002/jor.22038

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