Evaluation of BBB damage in an UV irradiation model by endogenous protein tracers.

@article{Lafuente1994EvaluationOB,
  title={Evaluation of BBB damage in an UV irradiation model by endogenous protein tracers.},
  author={Jose Vicente Lafuente and J{\'o}rge Cerv{\'o}s-Navarro and E Gutierrez Argando{\~n}a},
  journal={Acta neurochirurgica. Supplementum},
  year={1994},
  volume={60},
  pages={
          139-41
        }
}
Autologous serum proteins have proved to be suitable tracer to evaluate vascular permeability. The dynamic behaviour of anti-HRP immunoglobulins was studied in ultraviolet (UV) irradiation induced brain edema. Cerebral cortex of 36 anaesthetized adult rats was irradiated following a 2 x 2 mm parietal craniotomy. Immunization was carried out by 3 subcutaneous injections of 10 mg HRP in 0.5 ml complete freund adjuvant (CFA), 6, 4 and 2 weeks before the injury. Control animals were immunized only… CONTINUE READING
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