Evaluation of B-cell clonality using the BIOMED-2 PCR method effectively distinguishes cutaneous B-cell lymphoma from benign lymphoid infiltrates.

@article{Morales2008EvaluationOB,
  title={Evaluation of B-cell clonality using the BIOMED-2 PCR method effectively distinguishes cutaneous B-cell lymphoma from benign lymphoid infiltrates.},
  author={Anjali V Morales and Daniel Alan Arber and Katie Seo and Sabine Kohler and Youn Hee Kim and Uma Sundram},
  journal={The American Journal of dermatopathology},
  year={2008},
  volume={30 5},
  pages={425-30}
}
Primary cutaneous B-cell lymphomas (CBCL) are a diverse group of lymphomas that are limited to the skin at the time of diagnosis. Recently, standardized polymerase chain reaction protocols for immunoglobulin (Ig) rearrangement in nodal malignancies using the BIOMED-2 method have been studied extensively. However, reports of investigations of Ig clonality in CBCL using the BIOMED-2 method have been scant. We hypothesized that clonality detection in CBCL with the BIOMED-2 method could effectively… CONTINUE READING