Evaluation of Antibacterial Activity of Famotidine, Ranitidine and Cimetidine: In Vitro Study

  • Sinaa Abdul Amir, Kadhim Al Zubaidyand, Ali Ismail, Abdallah Al-Gareeb, Hayder Mteur Khaliel Al-Kuraishy, Kadhim Al Zubaidy
  • Published 2012

Abstract

Hayder M teur Khaliel Al-Kuraishy, Sinaa Abdul Amir Kadhim Al Zubaidyand Ali Ismail Abdallah Al-Gareeb 503 Abstract Background: Selective antihistamine receptor type 2 blockers like famotidine, ranitidine and cimetidine are widely used for treatment of peptic ulcer, and because many nonantibiotics agents have antibacterial activity. Aims:This study aimed to evaluate the antibacterial effects of famotidine, ranitidine and cimetidine. Material and methods: Tewnty two of bacterial isolates were selected and obtained from National Chemical Laboratory (NCL), from conjunctiva: 5 Staphylococcus aureus, 5 Escherichia coli,6 Pseudomonas aeruginosa and (6)Klebsiella pneumoniae. The drug's effects determined by Agar disc diffusion and Agar well diffusion methods,then evaluation done through measurment of zone of inhibition and minimal inhibitory concentration(MIC). Results: Results showed that cimetidine and ranitidine have non significant and negligible antibacterial effects, while famotidine have significant antibacterial effects (P≤ 0.01) against Escherichia coli (MIC8mg/ml and inhibition zone 25mm) and moderately against Staphylococcus aureus. Conclusions: famotidine have significant antibacterial activity especially against Escherichia coli. Keyword: antibacterial, cimetidine, famotidine and ranitidine نيديتمسلاو نيدتنا رلا و نيدتومافلا ءاودل ايرتكبمل داضملا ريثأتلا مييقت : مسجلا جراخ ةسا رد ةصلاخلا لا ةحرق جلاعل ا ريثك لمعتست نيديتمسلاو نيدتنا رلا و نيدتومافلا لثم تلابقتسملا نم يناثلا عونلاب ةصاخلا نيماتسيلا تاداضم :ةيفمخلا ةدعم . ديلاا يغلا تاداضملا نم ريثكلا كانى نلا نيديتمسلاو نيدتنا رلا و نيدتومافلا ءاودل ايرتكبمل داضملا ريثأتلا ميقت ىلا فديت ةسا ردلا هذى :ف ةيويح ر ايرتكبمل داضم رود ايل ناب دجو ةفورعملا . :لمعلا ةقيرطو داوملا 22 تريتخا ةيريتكب ةحسم 5 ايرتكبل اينم Staphylococcus aureus و, 5 E.coli و , 6 Pseudomonas

3 Figures and Tables

Cite this paper

@inproceedings{Amir2012EvaluationOA, title={Evaluation of Antibacterial Activity of Famotidine, Ranitidine and Cimetidine: In Vitro Study}, author={Sinaa Abdul Amir and Kadhim Al Zubaidyand and Ali Ismail and Abdallah Al-Gareeb and Hayder Mteur Khaliel Al-Kuraishy and Kadhim Al Zubaidy}, year={2012} }