Corpus ID: 212548277

Evaluation of Anti-diabetic Activity of Methanolic Extract of Coleus vettiveroides Jacob in Streptozotocin-induced Diabetic rats

  title={Evaluation of Anti-diabetic Activity of Methanolic Extract of Coleus vettiveroides Jacob in Streptozotocin-induced Diabetic rats},
  author={Gayathri Gopalakrishnan and C. K. Dhanapal},
Objective: The aim of the study was to evaluate the anti-diabetic activity of methanolic extract of Coleus Vettiveroides Jacob in streptozotocin induced diabetic rats. Methods: Streptozotocin was used to induce diabetes mellitus. The anti-diabetic potential was assessed by determining oral glucose tolerance, fasting blood glucose, urine glucose estimation, changes in body weight, Liver functions (SGPT and ALP), kidney functions (Urea and Creatinine), Pancreatic functions (Liver Glycogen and… Expand
1 Citations

Figures and Tables from this paper

Fractionated Ethanol Extract of Balanites aegyptiaca Fruit-Mesocarp Effect on Diabetes Mellitus Model Rats
Both aqueous and ethyl acetate extract-fractions of BAFM exert hypoglycaemic, antihyperglycaemic and antilipidaemic effects, however, the aQueous fraction was more potent. Expand


Protective Effect of Aqueous Extract of Uraria Picta on Acetaminophen Induced Nephrotoxicity in Rats
Nephrotoxicity can be produced by the excess use of NSAID (Non steroidal anti-inflammatory drugs) like Acetaminophen, it-induced liver necrosis and renal insufficiency occurs in approximately 1–2% ofExpand
Glycogen synthesis in the perfused liver of streptozotocin-diabetic rats.
Hepatic glycogen synthesis does not appear to be sensitive to either the short-term direct action of insulin (added alone to perfusions) of to long-term insulin deprivation in vivo, and the regulatory roles of substrates, insulin and glycogen synthetase in hepatic glycogens accumulation are discussed. Expand
Anticholestatic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis.
Picroliv showed a dose dependent choleretic activity as evidenced by increase in bile flow and its contents (bile salts and bile acids) and was more active than the known hepatoprotective drug silymarin. Expand
Protein measurement with the Folin phenol reagent.
Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein. Expand
Estimation of Plasma Phosphatase by Determination of Hydrolysed Phenol with Amino-antipyrine
The conditions under which enzymic hydrolysis is carried out are the same as in the King-Armstrong method, as modified by King (1951), the amino-antipyrine reagent (A.A.P.) being used to estimate the phenol liberated. Expand
The Importance of Individualized Pharmaceutical Therapy in the Treatment of Diabetes Mellitus
There are many clinically proven options available for the treatment of diabetes, and well-established guidelines regarding which intervention is the best option for patients with either type 1 or type 2 diabetes. Expand
This paper shall describe a method for the quantitative determination of both direct and indirect bilirubin in serum, in which protein precipitation and consequent loss of bilirubs have been eliminated and a quantitative study of the behavior of the direct, reaction has been made possible. Expand
Sex related differences in the susceptibility of rat to gentamicin nephrotoxicity ”
  • J . Infec Dis
  • 2012
  • K. Bangret, Clinical Chemistry Elsevier Limited.,
  • 2004
B . Phytochemical methods . In Chapman & , Hall
  • Raghunatha Iyer , Indian Medicinal Plants a Compendium of 500 Species
  • 1994