Evaluation of Amino-Oxyacetic Acid as a Palliative in Tinnitus

@article{Guth1990EvaluationOA,
  title={Evaluation of Amino-Oxyacetic Acid as a Palliative in Tinnitus},
  author={Paul S. Guth and Paul Blair and Charles H. Norris and John A. Risey and Hollis T. Reed and Gary D. Housley and Wayne Briner and Georgia M. Bryant and Robert Sean Miller},
  journal={Annals of Otology, Rhinology \& Laryngology},
  year={1990},
  volume={99},
  pages={74 - 79}
}
Amino-oxyacetic acid (AOAA) was evaluated as a palliative in tinnitus. Sixty-six patients with tinnitus presumed to be of cochlear origin were given either a placebo or 75 mg of AOAA four times a day for 1 week. Response was evaluated by both audiometric measurement of tinnitus loudness and subjective rating by patients of change or no change in tinnitus severity. Because loudness measurements and self-rating have not been shown to be independent, and since the aim of clinical treatment of… 

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References

SHOWING 1-10 OF 24 REFERENCES
Amino-oxyacetic acid as a palliative in tinnitus.
TLDR
Amino-oxyacetic acid, previously shown to cause a reversible loss of hearing sensitivity and a reduction in endocochlear potential, was tried as a palliative in human tinnitus and showed a substantial improvement in speech discrimination scores while receiving amino-oxyAcetic acid but not placebo.
Tinnitus: surgical treatment.
TLDR
Surgical management of tinnitus, although successful in some cases, does not provide a valid and reliable mode of treatment for subjective tinnita and implant procedures might be used in patients who suffer from severe tinnitis.
The use of intravenous lignocaine in the diagnosis and treatment of tinnitus.
TLDR
It is postulated that tinnitus in patients with Organ of Corti damage is the result of abnormal hyperactivity in the auditory pathway following deafferentation.
Trial of amino-oxyacetic acid, an anticonvulsant.
TLDR
It is concluded that this approach to anticonvulsant therapy is worth pursuing and that the drug may also find some use in the treatment of phenylketonuria and of seizures due to vitamin B(6) dependency.
The loudness of tinnitus.
TLDR
The loudness of tinnitus may be more intense than previously reported and the proposed method for measuring the loudness in this study appears to be a more valid measurement than the traditional method.
Critical masking bands for sensorineural tinnitus.
TLDR
The results suggest that certain masker bandwidths can be more efficient than others for the masking of tinnitus, and that masker characteristics deserve close attention in the design and fitting ofTinnitus-masker instruments.
Anticonvulsant properties of amino-oxyacetic acid.
TLDR
The anticonvulsant activity of AOAA did not appear to be due to increased GABA levels in the brain for the following reasons: a) maximum GABA levels occurred 6–8 hr after administration and it had fallen off markedly at 6 hr and Hydroxylamine, which has been reported to raise GABA l...
Neurotransmission in the auditory system: a primer for pharmacologists.
TLDR
There is an inertia in pharmacological thought which tends to produce continued interest and productivity in efferent and central systems but opposes efforts to move into nontraditional areas such as sensation, and with the still arguable exceptions of substance P and adenosine triphosphate none of the primary afferent transmitters has been identified.
The relation between the endocochlear potential and spontaneous activity in auditory nerve fibres of the cat.
TLDR
The relation between the endocochlear potential and spontaneous discharge rate in auditory nerve fibres was determined following intravenous injections of furosemide in anaesthetized cats as well as among high spontaneous rate fibres, the slope does not appear to vary systematically with the spontaneous rate of the fibre.
...
...