Evaluation of Amino-Oxyacetic Acid as a Palliative in Tinnitus

@article{Guth1990EvaluationOA,
  title={Evaluation of Amino-Oxyacetic Acid as a Palliative in Tinnitus},
  author={Paul S. Guth and Paul Blair and Charles H. Norris and John A. Risey and Hollis T. Reed and Gary D. Housley and Wayne Briner and Georgia M. Bryant and Robert Sean Miller},
  journal={Annals of Otology, Rhinology \& Laryngology},
  year={1990},
  volume={99},
  pages={74 - 79}
}
Amino-oxyacetic acid (AOAA) was evaluated as a palliative in tinnitus. Sixty-six patients with tinnitus presumed to be of cochlear origin were given either a placebo or 75 mg of AOAA four times a day for 1 week. Response was evaluated by both audiometric measurement of tinnitus loudness and subjective rating by patients of change or no change in tinnitus severity. Because loudness measurements and self-rating have not been shown to be independent, and since the aim of clinical treatment of… 
View on SAGE
ncbi.nlm.nih.gov
33 Citations
Background Citations
10
Methods Citations
1

Tables from this paper

33 Citations

Citation Type

Citation Type

PHARMACOLOGICAL TREATMENTS FOR TINNITUS: NEW AND OLD.
TLDR
Clinical trials are now underway to evaluate the efficacy of N-methyl-d-aspartate (NMDA) and dopamine D(2) antagonists, selective serotonin reuptake inhibitors (SSRIs), γ-aminobutyric acid (GABA) agonists and zinc dietary supplements, as well as animal behavioral studies suggest that GABA transaminase inhibitors and potassium channel modulators can suppress tinnitus.
Treatment Effects of Glutamate Antagonist for Tinnitus
TLDR
It is suggested that glutamate antagonists such as caroverine hydro chloride and memantine hydrochloride can be used as an alternative modality for treatment of subjective tinnitus.
Synthetic prostaglandin E1 misoprostol as a treatment for tinnitus.
TLDR
Findings support the contention that prostaglandins may be useful in the treatment of tinnitus, and further studies with larger samples are needed before widespread use of this intervention can be recommended.
Anticonvulsants for tinnitus.
TLDR
There is no evidence from studies performed so far to show that anticonvulsants have a large positive effect in the treatment of tinnitus but a small effect (of doubtful clinical significance) has been demonstrated.
A central nervous system approach to tinnitus
TLDR
There is no evidence from studies performed so far that the anticonvulsants gabapentin, carbamazepine, lamotrigine or flunarizine have a large positive effect in the treatment of tinnitus, but a small effect (of doubtful clinical significance) has been demonstrated.
Clonazepam Quiets tinnitus: a randomised crossover study with Ginkgo Biloba
TLDR
Comparing before and after each drug, clonazepam significantly improved tinnitus loudness, duration, annoyance, and tinnitis handicap inventory score, whereas the G biloba showed no significant differences on any of these measures.
Pediatric and Geriatric Tinnitus.
TLDR
There is no significant difference between children with tinnitus and those without in terms of hearing level, age, gender, or etiology of the deafness, and despite the fact that often children do not mention it, tinnitis may incite behavioral problems.
Neurophysiological model of tinnitus: Dependence of the minimal masking level on treatment outcome
Drug treatments for tinnitus: the Tulane experience.
It has recently been estimated that 12 million Americans have a severe form of tinnitus and that nearly 40 million Americans suffer from some form of tinnitus-related complaints [1]. The nature of…
Study of the Effect of Abnormalities in the External Ear Inducing Hearing Problems
TLDR
A parametric study involving the position, width and height of the anomaly as well as the sound velocity in the ear canal is conducted and the results make it possible to conclude on the effect of each parameter on the frequency response of an auditory canal with anomaly.
...
...

References

SHOWING 1-10 OF 24 REFERENCES
Amino-oxyacetic acid as a palliative in tinnitus.
TLDR
Amino-oxyacetic acid, previously shown to cause a reversible loss of hearing sensitivity and a reduction in endocochlear potential, was tried as a palliative in human tinnitus and showed a substantial improvement in speech discrimination scores while receiving amino-oxyAcetic acid but not placebo.
Tinnitus: surgical treatment.
TLDR
Surgical management of tinnitus, although successful in some cases, does not provide a valid and reliable mode of treatment for subjective tinnita and implant procedures might be used in patients who suffer from severe tinnitis.
The use of intravenous lignocaine in the diagnosis and treatment of tinnitus.
TLDR
It is postulated that tinnitus in patients with Organ of Corti damage is the result of abnormal hyperactivity in the auditory pathway following deafferentation.
Trial of amino-oxyacetic acid, an anticonvulsant.
TLDR
It is concluded that this approach to anticonvulsant therapy is worth pursuing and that the drug may also find some use in the treatment of phenylketonuria and of seizures due to vitamin B(6) dependency.
The loudness of tinnitus.
TLDR
The loudness of tinnitus may be more intense than previously reported and the proposed method for measuring the loudness in this study appears to be a more valid measurement than the traditional method.
Critical masking bands for sensorineural tinnitus.
TLDR
The results suggest that certain masker bandwidths can be more efficient than others for the masking of tinnitus, and that masker characteristics deserve close attention in the design and fitting ofTinnitus-masker instruments.
Anticonvulsant properties of amino-oxyacetic acid.
TLDR
The anticonvulsant activity of AOAA did not appear to be due to increased GABA levels in the brain for the following reasons: a) maximum GABA levels occurred 6–8 hr after administration and it had fallen off markedly at 6 hr and Hydroxylamine, which has been reported to raise GABA l...
Neurotransmission in the auditory system: a primer for pharmacologists.
TLDR
There is an inertia in pharmacological thought which tends to produce continued interest and productivity in efferent and central systems but opposes efforts to move into nontraditional areas such as sensation, and with the still arguable exceptions of substance P and adenosine triphosphate none of the primary afferent transmitters has been identified.
A permanent change in brain function resulting from daily electrical stimulation.
The relation between the endocochlear potential and spontaneous activity in auditory nerve fibres of the cat.
TLDR
The relation between the endocochlear potential and spontaneous discharge rate in auditory nerve fibres was determined following intravenous injections of furosemide in anaesthetized cats as well as among high spontaneous rate fibres, the slope does not appear to vary systematically with the spontaneous rate of the fibre.
...
...