Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model.

@article{Southwood2004EvaluationOA,
  title={Evaluation of Ad-BMP-2 for enhancing fracture healing in an infected defect fracture rabbit model.},
  author={L L Southwood and David D Frisbie and Christopher E. Kawcak and Steven C. Ghivizzani and Christopher H. Evans and C. Wayne Mcilwraith},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2004},
  volume={22 1},
  pages={
          66-72
        }
}
The objective of this study was to evaluate the use of adenoviral transfer of the BMP-2 gene (Ad-BMP-2) for enhancing healing in an infected defect fracture model. A femoral defect stabilized with plates and screws was surgically created in sixty-four skeletally mature New Zealand white rabbits. Experimental groups were: (1) non-infected Ad-luciferase (Ad-LUC, NONLUC), (2) non-infected Ad-BMP-2 (NONBMP), (3) infected Ad-LUC (INFLUC), and (4) infected Ad-BMP-2 (INFBMP). A sclerosing agent was… CONTINUE READING
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