• DOI:10.5402/2012/789651
• Corpus ID: 17217635

Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre

@article{Sireeratawong2012EvaluationOA,
  title={Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre},
  author={Seewaboon Sireeratawong and Supaporn Vannasiri and Urarat Nanna and Tipaya Singhalak and Kanjana Jaijoy},
  journal={ISRN Pharmacology},
  year={2012},
  volume={2012}
}

• S. Sireeratawong, Supaporn Vannasiri, +2 authors K. Jaijoy
• Published 20 March 2012
• Medicine
• ISRN Pharmacology

We studied an acute and chronic oral toxicity of the extract from Ziziphus attopensis (ZA) in male and female SD rats according to the OECD guidelines. After a single oral administration of ZA 5 g/kg body weight, measurement of the body and organs, necropsy, and health monitoring were performed. The body and organ weights and behavior were not changed relative to the control rats indicating that ZA does not produce acute toxicity. The chronic toxicity was determined by oral feeding both male and female rats daily with ZA at the doses of 1, 2, 4, and 8 g/kg body weight for 180 days. Body weight changes, hematological and biochemical parameters, organ weights, gross finding, and histopathology examination were monitored during the experimental period. The results did not show any differences from the control groups. Analyses of these results with the information of signs, behavior, and health monitoring can lead to a conclusion that the long-term oral administration of ZA for 180 days does not cause chronic toxicity.