Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre

  title={Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre},
  author={Seewaboon Sireeratawong and Supaporn Vannasiri and Urarat Nanna and Tipaya Singhalak and Kanjana Jaijoy},
  journal={ISRN Pharmacology},
We studied an acute and chronic oral toxicity of the extract from Ziziphus attopensis (ZA) in male and female SD rats according to the OECD guidelines. After a single oral administration of ZA 5 g/kg body weight, measurement of the body and organs, necropsy, and health monitoring were performed. The body and organ weights and behavior were not changed relative to the control rats indicating that ZA does not produce acute toxicity. The chronic toxicity was determined by oral feeding both male… 

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