Evaluation of Accumulated Mucopolysaccharides in the Brain of Patients with Mucopolysaccharidoses by 1H-Magnetic Resonance Spectroscopy before and after Bone Marrow Transplantation

@article{Takahashi2001EvaluationOA,
  title={Evaluation of Accumulated Mucopolysaccharides in the Brain of Patients with Mucopolysaccharidoses by 1H-Magnetic Resonance Spectroscopy before and after Bone Marrow Transplantation},
  author={Yukitoshi Takahashi and Kazuko Sukegawa and Minako Aoki and Akiko Ito and Kiyotaka Suzuki and Heima Sakaguchi and Mizuho Watanabe and Kouji Isogai and Shinji Mizuno and Hiroaki Hoshi and Kazuo Kuwata and Shunji Tomatsu and Shunichi Kato and Tsuyoshi Ito and Naomi Kondo and Tadao Orii},
  journal={Pediatric Research},
  year={2001},
  volume={49},
  pages={349-355}
}
In seven patients with mucopolysaccharidoses (1 Hurler, 1 Hurler-Scheie, 4 Hunter, 1 Sly), cranial 1H-magnetic resonance spectroscopy was performed to evaluate the accumulation of mucopolysaccharides and biochemical changes in the CNS in vivo before and after bone marrow transplantation (BMT). In two of seven patients, 1H-magnetic resonance spectroscopy was performed before and after BMT. Nuclear magnetic resonance spectra of dermatan sulfate and chondroitin sulfate-C and magnetic resonance… CONTINUE READING