Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates.

  title={Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates.},
  author={Samia Ait-Mohand and Patrick Fournier and V{\'e}ronique Dumulon-Perreault and Garry E Kiefer and Paul Jurek and Cara L. Ferreira and François B{\'e}nard and Brigitte Gu{\'e}rin},
  journal={Bioconjugate chemistry},
  volume={22 8},
Several bifunctional chelates (BFCs) were investigated as carriers of (64)Cu for PET imaging. The most widely used chelator for (64)Cu labeling of BFCs is DOTA (1,4,7,10-tetraazacyclododecane-N,N',N″,N'''-tretraacetic acid), even though this complex exhibits only moderate in vivo stability. In this study, we prepared a series of alternative chelator-peptide conjugates labeled with (64)Cu, measured in vitro receptor binding affinities in human breast cancer T47D cells expressing the gastrin… CONTINUE READING