Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study

@inproceedings{Brophy2009EvaluationO6,
  title={Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study},
  author={Karen M Brophy and Anthony W. Ryan and Graham D Turner and Valerie I Trimble and Kunal D. Patel and Colm O'mor{\'a}in and Nicholas P Kennedy and Brian J Egan and Eimear Close and Garrett O Lawlor and Padraic Macmathuna and Fiona M. Stevens and Mohamed Abuzakouk and Conleth Feighery and Dermot P. Kelleher and Ross McManus},
  booktitle={BMC Medical Genetics},
  year={2009}
}
Recent whole genome analysis and follow-up studies have identified many new risk variants for coeliac disease (CD, gluten intolerance). The majority of newly associated regions encode candidate genes with a clear functional role in T-cell regulation. Furthermore, the newly discovered risk loci, together with the well established HLA locus, account for less than 50% of the heritability of CD, suggesting that numerous additional loci remain undiscovered. Linkage studies have identified some well… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 48 references

PLINK: a tool set for whole-genome association and population-based linkage analyses.

American journal of human genetics • 2007
View 4 Excerpts
Highly Influenced

GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism

M Raymond, F Rousset
J Heredity • 1995
View 2 Excerpts
Highly Influenced

Differential haplotypic expression of the interleukin-18 gene

European Journal of Human Genetics • 2007
View 1 Excerpt

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