Evaluation of 24-hour infusion of high-dose methotrexate —Pharmacokinetics and toxicity

@article{Goh1979EvaluationO2,
  title={Evaluation of 24-hour infusion of high-dose methotrexate —Pharmacokinetics and toxicity},
  author={Ten S Goh and Ka Yan Wong and Beatrice Lampkin and J O'leary and David Gnarra},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1979},
  volume={3},
  pages={177-180}
}
High-dose methotrexate was administered by constant infusion over 24 h to children with various malignancies. Citrovorum factor was given at the completion of methotrexate infusion and continued for 72 h. Serum concentration of 10-4 M could be sustained for 24 h with doses of methotrexate over 100 mg/kg. This infusion regimen was well tolerated and only… CONTINUE READING