Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry.

  title={Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry.},
  author={Dezheng Huo and Yonglan Zheng and Temidayo Ogundiran and Clement Adebamowo and Katherine L Nathanson and Susan Domchek and Timothy R. Rebbeck and Michael S Simon and Esther M John and Anselm J. M. Hennis and Barbara Nemesure and S Y Wu and Maria Cristina Leske and Stefan Ambs and Qun Niu and Jing Zhang and Nancy J. Cox and Olufunmilayo I. Olopade},
  volume={33 4},
Multiple breast cancer susceptibility loci have been identified in genome-wide association studies (GWAS) in populations of European and Asian ancestry using array chips optimized for populations of European ancestry. It is important to examine whether these loci are associated with breast cancer risk in women of African ancestry. We evaluated 25 single nucleotide polymorphisms (SNPs) at 19 loci in a pooled case-control study of breast cancer, which included 1509 cases and 1383 controls. Cases… CONTINUE READING
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