Evaluation of 18F-annexin V as a PET imaging agent in an animal model of apoptosis.

@article{Yagle2005EvaluationO1,
  title={Evaluation of 18F-annexin V as a PET imaging agent in an animal model of apoptosis.},
  author={Kevin J. Yagle and J. F. Eary and Jonathan F. Tait and J. R. Grierson and Jeanne M. Link and Barbara Lewellen and Don F Gibson and Kenneth A. Krohn},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2005},
  volume={46 4},
  pages={658-66}
}
UNLABELLED Annexin V is a 36-kDa protein that binds with high affinity to phosphatidylserine lipids in the cell membrane. Because one of the earliest measurable events in apoptosis is the eversion of phosphatidylserine from the inner membrane leaflet to the outer cell surface, annexin V has proven useful for detecting the earliest stages of apoptosis. METHODS Annexin V was radiolabeled with 18F using N-succinimidyl-4-18F-fluorobenzoic acid chemistry, to a specific activity of 555-925 kBq/mug… CONTINUE READING
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