Evaluation of 13q14 status in patients with chronic lymphocytic leukemia using single nucleotide polymorphism-based techniques.

@article{Hanlon2009EvaluationO1,
  title={Evaluation of 13q14 status in patients with chronic lymphocytic leukemia using single nucleotide polymorphism-based techniques.},
  author={Katy Hanlon and Sian Ellard and Claudius E. Rudin and Susan Thorne and Teresa Davies and Lorna W Harries},
  journal={The Journal of molecular diagnostics : JMD},
  year={2009},
  volume={11 4},
  pages={
          298-305
        }
}
Deletions of chromosome 13q14 are common in chronic lymphocytic leukemia and other cancers, demonstrating the importance of this region in tumorigenesis. We report the use of two single-nucleotide polymorphism (SNP)-based techniques to determine 13q loss of heterozygosity (LOH) status in 15 patients with CLL: (i) digital SNP (dSNP), where analysis of heterozygous SNPs detects allelic imbalances, and (ii) DNA sequencing, where LOH is identified by comparison of allelic peak heights in normal and… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 20 REFERENCES

cancers

  • K Schlade-Bartusiak, A Stembalska, D Ramsey
  • 2006

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