Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain.

@article{Parker2014EvaluationO1,
  title={Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain.},
  author={Christine A. Parker and Nabeel Nabulsi and Daniel E Holden and Shu-Fei Lin and Tara Cass and David C Labaree and Steven Kealey and Antony D. Gee and Stephen Husbands and Darren R. Quelch and Richard E. Carson and David J. Nutt and Yiyun Huang and Robin J. Tyacke},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2014},
  volume={55 5},
  pages={838-44}
}
UNLABELLED The development of a PET radioligand selective for I2-imidazoline binding sites (I2BS) would enable, for the first time, specific, measurable in vivo imaging of this target protein, along with assessment of alterations in expression patterns of this protein in disease pathophysiology. METHODS BU99008 was identified as the most promising I2BS radioligand candidate and radiolabeled with (11)C via methylation. The in vivo binding properties of (11)C-BU99008 were assessed in rhesus… CONTINUE READING
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