Evaluation of (111)In-labeled macrocyclic chelator-amino acid derivatives for cancer imaging.

@article{Lee2012EvaluationO,
  title={Evaluation of (111)In-labeled macrocyclic chelator-amino acid derivatives for cancer imaging.},
  author={Jong Jin Lee and Dinesh Shetty and Yun-Sang Lee and Sang Eun Kim and Young Joo Kim and M K Hong and Ji Yeon Son and Jae Min Jeong},
  journal={Nuclear medicine and biology},
  year={2012},
  volume={39 3},
  pages={
          325-33
        }
}
PURPOSE We evaluated new (111)In-labeled amino acid derivatives, in which the amino acids are conjugated with1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetraacetic acid (DOTA), 1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (DO2A) or 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A). METHODS DOTA-aminoalanine (DOTA-A), DOTA-aminohomoalanine (DOTA-H), DOTA-lysine (DOTA-L), DO2A-alanine (DO2A-A), DO3A-alanine (DO3A-A) and DO3A-homoalanine (DO3A-H) were labeled with (111)In. In vitro… Expand
4 Citations
Biological evaluation of new [(18) F]F-labeled synthetic amino acid derivatives as oncologic radiotracers.
TLDR
The present study evaluated the tumoral uptake of the novel synthetic amino acid positron emission tomography (PET) tracers and indicated the potential uses of these new synthetic amino acids as oncologic radiotracers. Expand
Development of (68)Ga-labeled multivalent nitroimidazole derivatives for hypoxia imaging.
TLDR
The trivalent agent showed the highest tumor uptake in biodistribution and animal PET studies using CT-26 xenografted mice and successfully synthesized multivalent (68)Ga-labeled NI derivatives for imaging hypoxia. Expand
Metal Based Imaging Probes of DO3A-Act-Met for LAT1 Mediated Methionine Specific Tumors : Synthesis and Preclinical Evaluation
TLDR
DO3A-Act-Met, a methionine conjugated probe is a promising agent for targeted molecular imaging, exhibiting high specificity towards tumor owing to its essential role in proliferation of cancer cells mediated through LAT1. Expand
Zinc complex of tryptophan appended 1,4,7,10-tetraazacyclododecane as potential anticancer agent: Synthesis and evaluation.
TLDR
In vivo tumor specificity of the developed ligand was validated after radiocomplexation with 99mTc (>98% radiochemical yield and specific activity of 2.56GBq/µmol). Expand

References

SHOWING 1-10 OF 31 REFERENCES
Synthesis of novel 68Ga-labeled amino acid derivatives for positron emission tomography of cancer cells.
TLDR
These derivatives were found to have high labeling efficiencies, high stabilities, high tumor cell uptakes, high tumors/nontumor xenograft uptakes and low nonspecific uptake in normal organs, except for the kidneys. Expand
Preparation of a Promising Angiogenesis PET Imaging Agent: 68Ga-Labeled c(RGDyK)–Isothiocyanatobenzyl-1,4,7-Triazacyclononane-1,4,7-Triacetic Acid and Feasibility Studies in Mice
TLDR
Stable 68Ga-NOTA-RGD was obtained in a straightforward manner at a high yield and showed a high affinity for αvβ3 integrin, specific uptake by angiogenic muscles, a high level of uptake by tumors, and rapid renal excretion. Expand
Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography.
TLDR
The synthesized compounds showed high tumor uptakes in vitro and in vivo, and had high labeling yields and excellent stabilities, which might motivate the use of (68)Ga amino acid PET for tumor diagnosis. Expand
Synthesis and evaluation of [18F]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors.
  • T. Shoup, J. Olson, +7 authors M. Goodman
  • Medicine
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1999
TLDR
The amino acid FACBC can be radiofluorinated for clinical use and is a potential PET tracer for tumor imaging, evaluated for its potential in tumor localization. Expand
Preparation and investigation of tumor affinity, uptake kinetic and transport mechanism of iodine-123-labelled amino acid derivatives in human pancreatic carcinoma and glioblastoma cells.
TLDR
Results of the present investigation indicated that ITIC is not taken up into tumor cells via the common neutral amino acid carrier systems, including the A, L and ASC system, and preloading with naturally occurring L-amino acids failed to stimulate the cellular uptake of the radiopharmaceuticals. Expand
Synthesis and radiopharmacology of O-(2-[18F]fluoroethyl)-L-tyrosine for tumor imaging.
TLDR
The high in vivo stability of L-FET, its fast brain and tumor uptake kinetics, its low accumulation in nontumor tissue and its ease of synthesis strongly support further evaluation of L-[18F]FET as an amino acid tracer for cerebral and peripheral tumors. Expand
Synthesis of 68Ga-labeled DOTA-nitroimidazole derivatives and their feasibilities as hypoxia imaging PET tracers.
TLDR
Two nitroimidazole derivatives were synthesized by conjugating nitroIMidazoles and 1,4,7,10-tetraazacyclodododecane-1,4-7, 10-Tetraacetic acid (DOTA) via an amide bond and a thiourea bond and both showed higher uptake in cancer cell lines cultured under hypoxic condition than under normoxic condition. Expand
Feasibility of fluorine-18-fluorophenylalanine for tumor imaging compared with carbon-11-L-methionine.
  • K. Kubota, K. Ishiwata, +5 authors T. Ido
  • Chemistry, Medicine
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1996
TLDR
Fluorine-18-Phe seems to be a potentially useful amino acid tracer for tumor imaging with a longer half-life than 11C, with higher tumor contrast in the abdomen than Met and a similar sensitive response to radiotherapy. Expand
Pharmacokinetics of 3-[125I]iodo-alpha-methyl-L-tyrosine, a tumor imaging agent, after probenecid loading in mice implanted with colon cancer DLD-1 cells.
TLDR
It is confirmed that [125I]IMT transport is predominantly mediated by l-type amino acid transporter-1 in DLD-1 cells and uptake is mediated by organic anion and amino acid transporters in the kidney. Expand
Synthesis and characterization of nitroimidazole derivatives for 68Ga-labeling and testing in tumor xenografted mice.
TLDR
(68)Ga labeled NI derivatives for hypoxic tissue imaging were successfully developed and it was proved that amide oxygen of Ga-NOTA-NI contributes to the formation of metal complex by X-ray crystallography. Expand
...
1
2
3
4
...