Evaluation of [4-O-methyl-(11)C]KW-6002 as a potential PET ligand for mapping central adenosine A(2A) receptors in rats.

Abstract

KW-6002, a xanthine-based adenosine A(2A) antagonist, was labelled with the positron emitter carbon-11 by O-methylation of its precursor, KF23325, using [(11)C]iodomethane and was evaluated in rats as a putative in vivo radioligand for positron emission tomography (PET). Following intravenous injection of [(11)C]KW-6002, radioactivity was measured in blood… (More)

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@article{Hirani2001EvaluationO, title={Evaluation of [4-O-methyl-(11)C]KW-6002 as a potential PET ligand for mapping central adenosine A(2A) receptors in rats.}, author={Ella Hirani and Jana K Gillies and A. Karasawa and J Workman T Shimada and Hiroshi Kase and Jolanta Opacka-Juffry and Salih Osman and Soumya Luthra and S. P. Hume and Denise Brooks}, journal={Synapse}, year={2001}, volume={42 3}, pages={164-76} }