Evaluation of (99m)Tc-HYNIC-TMTP1 as a tumor-homing imaging agent targeting metastasis with SPECT.

@article{Li2015EvaluationO,
  title={Evaluation of (99m)Tc-HYNIC-TMTP1 as a tumor-homing imaging agent targeting metastasis with SPECT.},
  author={Fei Li and Teng Cheng and Qingjian Dong and Rui Wei and Zhenzhong Zhang and Danfeng Luo and Xiangyi Ma and Shixuan Wang and Qinglei Gao and Ding Ma and Xiaohua Zhu and Ling Xi},
  journal={Nuclear medicine and biology},
  year={2015},
  volume={42 3},
  pages={256-62}
}
INTRODUCTION TMTP1 (NVVRQ) is a novel tumor-homing peptide, which specifically targets tumor metastases, even at the early stage of occult metastasis foci. Fusing TMTP1 to therapeutic peptides or proteins can increase its anti-cancer efficacy both in vivo and in vitro. Here, we labeled TMTP1 with (99m)Tc to evaluate its targeting properties in an ovarian cancer xenograft tumor mouse model and a gastric cancer xenograft mouse model. METHODS The invasion ability of SKOV3 and highly metastatic… CONTINUE READING