Evaluating therapeutic targets for reperfusion-related brain hemorrhage.

  title={Evaluating therapeutic targets for reperfusion-related brain hemorrhage.},
  author={Carolina Magdalene Maier and Lily B. Hsieh and Trisha Crandall and Purnima Narasimhan and Pak Hoo Chan},
  journal={Annals of neurology},
  volume={59 6},
OBJECTIVE Early reperfusion after an ischemic stroke can cause blood-brain barrier injury with subsequent cerebral edema and devastating brain hemorrhage. These complications of early reperfusion, which result from excess production of reactive oxygen species, significantly limit the benefits of stroke therapies. In this article, we use a novel animal model that facilitates identification of specific components of the reperfusion injury process, including vascular injury and secondary brain… CONTINUE READING
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