Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis.

@article{Fisher2002EvaluatingTS,
  title={Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis.},
  author={Anna Astriab Fisher and Dongjiu Ye and Dimitri S. Sergueev and Michael Herbert Fisher and Barbara Ramsay Shaw and Rudolph L Juliano},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 25},
  pages={
          22980-4
        }
}
Antisense oligonucleotides are potentially powerful tools for selective control of cellular and viral gene expression. Crucial to successful application of this approach is the specificity of the oligonucleotide for the chosen RNA target. Here we apply DNA array technology to examine the specificity of antisense oligonucleotide treatments. The molecules used in these studies consisted of phosphorothioate oligomers linked to the Antennapedia (Ant) delivery peptide. The antisense oligonucleotide… CONTINUE READING
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