Evaluating the role of therapy in histiocytosis-X. Clinical studies, staging, and scoring.

Histiocytosis-X is a difficult disease on which to perform clinical studies. It is a rare disease, with great clinical heterogeneity. The natural history is characterized by periods of spontaneous disease stabilization, remission, and exacerbation. Clinical care is given by several diverse types of physicians. Several suggestions are made for the optimal… (More)