Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

  title={Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.},
  author={Julien Couthouis and Michael P. Hart and Renske Erion and Oliver D. King and Zamia Diaz and Tadashi Nakaya and Fadia Ibrahim and Hyung-Jun Kim and Jelena Mojsilovic-Petrovic and Saarene Panossian and Cecilia Kim and Edward C. Frackelton and Jennifer A. Solski and Kelly L Williams and Dana Clay-Falcone and L. B. Elman and Leo McCluskey and Robert H. Greene and Hakon Hakonarson and Robert Gordon Kalb and Virginia M-Y Lee and John Q. Trojanowski and Garth A. Nicholson and Ian P. Blair and Nancy M Bonini and Vivianna M Van Deerlin and Zissimos Mourelatos and James Shorter and Aaron D Gitler},
  journal={Human molecular genetics},
  volume={21 13},
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Mutations in related RNA-binding proteins TDP-43, FUS/TLS and TAF15 have been connected to ALS. These three proteins share several features, including the presence of a bioinformatics-predicted prion domain, aggregation-prone nature in vitro and in vivo and toxic effects when expressed in multiple model systems. Given these commonalities, we hypothesized that a related protein, EWSR1 (Ewing sarcoma… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 94 extracted citations


Publications referenced by this paper.
Showing 1-10 of 58 references

A hexanucleotide repeat expansion in C 9 ORF 72 is the cause of chromosome 9 p 21 - linked ALS - FTD

  • A. E. Renton, E. Majounie, +7 authors L. Myllykangas
  • 2011

Similar Papers

Loading similar papers…