Evaluating the role of orexins in the pathophysiology and treatment of depression: A comprehensive review

@article{Shariq2019EvaluatingTR,
  title={Evaluating the role of orexins in the pathophysiology and treatment of depression: A comprehensive review},
  author={Aisha S. Shariq and Joshua D. Rosenblat and Asem A Alageel and Rodrigo B. Mansur and Carola Rong and Roger Chun-Man Ho and Renee-Marie Ragguett and Zihang Pan and Elisa Brietzke and Roger S. McIntyre},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2019},
  volume={92},
  pages={1-7}
}

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References

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Role of Orexin in the Pathophysiology of Depression: Potential for Pharmacological Intervention

TLDR
An overview of human and animal research dedicated to the study of the specific involvement of orexins in depression is provided, and a framework in which disturbances of the orexinergic system are regarded as an integral component of the etiology of depression is proposed.

Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.

TLDR
The synthesis of dual antagonists of orexin receptors are synthesised and these drugs, as opposed to benzodiazepines, do not change the sleep architecture and have limited side-effects.

Neurogenesis-Independent Antidepressant-Like Effects on Behavior and Stress Axis Response of a Dual Orexin Receptor Antagonist in a Rodent Model of Depression

TLDR
This is the first evidence that pharmacological blockade of the orexinergic system induces a robust antidepressant-like effect and the restoration of stress-related HPA axis defect independently from a neurogenic action.

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

TLDR
Dosed orally Suvorexant significantly and dose-dependently reduced locomotor activity and promoted sleep in rats, dogs, and rhesus monkeys, highlighting a unique opportunity to develop dual orexin antagonists as a novel therapy for insomnia.
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