Evaluating the pharmacokinetics and in vivo cancer targeting capability of Au nanocages by positron emission tomography imaging.

@article{Wang2012EvaluatingTP,
  title={Evaluating the pharmacokinetics and in vivo cancer targeting capability of Au nanocages by positron emission tomography imaging.},
  author={Yucai Wang and Yongjian Liu and Hannah P. Luehmann and Xiaohu Xia and Peter J. Brown and Chad Michael Jarreau and Michael Welch and Younan Xia},
  journal={ACS nano},
  year={2012},
  volume={6 7},
  pages={
          5880-8
        }
}
Gold nanocages have recently emerged as a novel class of photothermal transducers and drug carriers for cancer treatment. However, their pharmacokinetics and tumor targeting capability remain largely unexplored due to the lack of an imaging modality for quick and reliable mapping of their distributions in vivo. Herein, Au nanocages were prepared with controlled physicochemical properties and radiolabeled with (64)Cu in high specific activities for in vivo evaluation using positron emission… CONTINUE READING
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