Evaluating the performance of models for predicting the BRCA germline mutations in Han Chinese familial breast cancer patients

@article{Rao2008EvaluatingTP,
  title={Evaluating the performance of models for predicting the BRCA germline mutations in Han Chinese familial breast cancer patients},
  author={Nan-Yan Rao and Zhen Hu and Jinming Yu and Wen-feng Li and Bin Zhang and Feng-xi Su and Jiong Wu and Zhen-zhou Shen and Wei Huang and Graham A Colditz},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={116},
  pages={563-570}
}
Purpose Established models (Penn, Myraid and BRCApro) are useful of estimating the probability that a person has a BRCA mutation. But the value of these models in Chinese population is unclear. The aim of the study is to evaluate the performance of three models on the assisting in pre-test genetic risk counseling. Methods Three risk assessment models, Penn II, Myriad and BRCApro, were applied to 212 familial breast cancer patients who had undergone BRCA1/2 mutation analysis. Sensitivity… CONTINUE READING