Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats.

@article{Wali2016EvaluatingTN,
  title={Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats.},
  author={Bushra Wali and Iqbal Sayeed and David B Guthrie and Michael G. Natchus and Nefize Turan and Dennis C Liotta and Donald G. Stein},
  journal={Neuropharmacology},
  year={2016},
  volume={109},
  pages={148-158}
}
The poor aqueous solubility of progesterone (PROG) limits its potential use as a therapeutic agent. We designed and tested EIDD-1723, a novel water-soluble analog of PROG with >100-fold higher solubility than that of native PROG, as candidate for development as a field-ready treatment for traumatic brain injury (TBI). The pharmacokinetic effects of EIDD-1723 on morphological and functional outcomes in rats with bilateral cortical impact injury were evaluated. Following TBI, 10-mg/kg doses of… CONTINUE READING
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