Evaluating the near-term infant for early onset sepsis: progress and challenges to consider with 16S rDNA polymerase chain reaction testing.

@article{Jordan2006EvaluatingTN,
  title={Evaluating the near-term infant for early onset sepsis: progress and challenges to consider with 16S rDNA polymerase chain reaction testing.},
  author={Jeanne Ann Jordan and Mary Beth Durso and Allyson R Butchko and Judith G Jones and Beverly Sobchak Brozanski},
  journal={The Journal of molecular diagnostics : JMD},
  year={2006},
  volume={8 3},
  pages={357-63}
}
Although the rate of early onset sepsis in the near-term neonate is low (one to eight of 1,000 cases), the rate of mortality and morbidity is high. As a result, infants receive multiple, broad-spectrum antibiotic therapy, many for up to 7 days despite blood cultures showing no growth. Maternal intrapartum antibiotic prophylaxis and small blood volume collections from infants are cited as reasons for the lack of confidence in negative culture results. Incorporating an additional, more rapid test… CONTINUE READING

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