Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?

@article{Showalter2008EvaluatingTD,
  title={Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?},
  author={Shayna L. Showalter and Timothy N. Showalter and Agnes Witkiewicz and Robert Havens and Eugene P. Kennedy and Tomas Hucl and Scott E. Kern and Charles J Yeo and Jonathan R. Brody},
  journal={Cancer biology & therapy},
  year={2008},
  volume={7 7},
  pages={986-94}
}
Thymidylate synthase is a target of 5-fluoruracil, a pyrimidine analog used to treat gastrointestinal and other cancers. The 5-fluorouracil metabolite, fluoro-deoxyuridine monophosphate, forms a ternary complex with thymidylate synthase and 5,10-methylene tetrahydrofolate. The purpose of this study was to evaluate the time-honored connection between thymidylate synthase and 5-fluorouracil. From our literature search spanning reports from 1995 to 2007 published in journals having an impact… CONTINUE READING