Evaluating the contribution of genetic and familial shared environment to common disease using the UK Biobank

@inproceedings{Muoz2016EvaluatingTC,
  title={Evaluating the contribution of genetic and familial shared
environment to common disease using the UK Biobank},
  author={Mar{\'i}a Luisa Mu{\~n}oz and Ricardo Pong-Wong and Oriol Canela-Xandri and Konrad Rawlik and Chris S. Haley and Albert Tenesa},
  booktitle={Nature Genetics},
  year={2016}
}
Genome-wide association studies have detected many loci underlying susceptibility to disease, but most of the genetic factors that contribute to disease susceptibility remain unknown. Here we provide evidence that part of the 'missing heritability' can be explained by an overestimation of heritability. We estimated the heritability of 12 complex human diseases using family history of disease in 1,555,906 individuals of white ancestry from the UK Biobank. Estimates using simple family-based… CONTINUE READING
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