Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.

@article{Kovacs2017EvaluatingTP,
  title={Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.},
  author={Gabor G Kovacs and John L. Robinson and Sharon X Xie and Edward K. B. Lee and Murray Grossman and David A. Wolk and David J Irwin and Dan Weintraub and Christopher F. Kim and Theresa Schuck and Ahmed A. Abdel-Haleem Yousef and Stephanie T Wagner and Eunran Suh and Vivianna M Van Deerlin and Virginia M-Y Lee and John Q. Trojanowski},
  journal={Journal of neuropathology and experimental neurology},
  year={2017},
  volume={76 4},
  pages={
          270-288
        }
}
The term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in astrocytes. We evaluated the correlates of ARTAG types (i.e., subpial, subependymal, white and gray matter, and perivascular) in different neuroanatomical regions. Clinical, neuropathological, and genetic (eg, APOE ε4 allele, MAPT H1/H2 haplotype) data from 628 postmortem brains from subjects were investigated; most of the patients had been longitudinally followed… CONTINUE READING
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