Evaluating the Impact of COVID-19 on Male Reproduction.

@article{Tian2020EvaluatingTI,
  title={Evaluating the Impact of COVID-19 on Male Reproduction.},
  author={Yu Tian and Li-quan Zhou},
  journal={Reproduction},
  year={2020}
}
Invasion or damage of the male reproductive system is one of the reported outcomes of viral infection. Current studies have documented that SARS-CoV-2, which causes COVID-19, can damage the male reproductive system in large part by inflammatory damage caused by cytokine storm. However, whether SARS-CoV-2 can infect the human testis directly and enter semen is controversial. Other adverse effects of SARS-CoV-2 on male reproduction are also of concern and require comprehensive evaluation. Here… Expand

Tables from this paper

The impact of COVID-19 on the male reproductive tract and fertility: A systematic review
TLDR
Results show little evidence for the presence of viral RNA in semen, although COVID-19 seems to affect seminal parameters, induce orchitis, and cause hypogonadism. Expand
Possible Male Reproduction Complications after Coronavirus Pandemic
TLDR
Evidence suggests that male gonads may be potentially vulnerable to SARS-CoV-2 infection and suggested preventive solutions are discussed. Expand
COVID-19 and male reproductive system: pathogenic features and possible mechanisms
TLDR
This study reviewed articles related to COVID-19 and male reproductive system to find the possible underlying mechanisms of SARS-CoV-2 in affecting male fertility and investigates potential mechanisms of male infertility in survivals of CO VID-19. Expand
The Impact of SARS-CoV-2 Infection on Fertility and Female and Male Reproductive Systems
TLDR
This article aimed to review the latest literature regarding the potential effects of SARS-CoV-2 infection on female and male reproductive systems as well as fertility, in general. Expand
Crosstalk between SARS-CoV-2 and Testicular Hemostasis: Perspective View
  • R.G. Ahmed
  • Medicine
  • Biotechnology to Combat COVID-19 [Working Title]
  • 2021
TLDR
This chapter not only showed the sexual transmission of SARS-CoV-2 but also followed its impact on sexual behavior, pregnancy, and progeny, indicating that maintaining the testicular hemostasis may play a vital role in a healthy life for the offspring. Expand
Impact du SARS-CoV-2 sur la fertilité, les gamètes et l’Assistance médicale à la procréation
TLDR
Most recent studies are based on the effects of the infectious syndrome, on hormonal factors as well as on the expression of viral entry proteins in cells involved in gametogenesis, to assess the impact of COVID -19, and no effect on female gametes was highlighted. Expand
Male infertility and COVID-19: Is there a relationship?
TLDR
The clinical pathophysiology and the mechanisms involved in the genesis of male infertility from COVID-19 are analyzed, through the critical analysis of the main scientific evidence on the subject presented so far. Expand
Early and late endocrine complications of COVID-19
TLDR
The majority of the available data refer to glucose dysregulation and its reciprocal effect on COVID-19 infection with the main interest focusing on the presentation of new onset of diabetes mellitus. Expand
Causes of respiratory failure in COVID-19 patients
TLDR
The different factors triggering respiratory failure due to COVID19 infecton as the main cause of death and the deteminants of its susceptibility in a population is also focused. Expand
Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues
TLDR
Interestingly, TMPRSS2 expression levels were positively correlated with the enrichment levels of four immune signatures in SARS-CoV-2-infected patients but likely to be negatively correlated with them in the normal lung tissue. Expand
...
1
2
...

References

SHOWING 1-10 OF 103 REFERENCES
Sex differences in immune responses that underlie COVID-19 disease outcomes
TLDR
Examination of sex differences in viral loads, SARS-CoV-2-specific antibody titres, plasma cytokines and blood-cell phenotyping in patients with moderate COVID-19 found that a poor T cell response negatively correlated with patients’ age and was associated with worse disease outcome in male patients, but not in female patients. Expand
Impaired spermatogenesis in COVID-19 patients
TLDR
Impairment of spermatogenesis was observed in COVID-19 patients, which could be partially explained as a result of an elevated immune response in testis, and autoimmune orchitis occurred in some COVID -19 patients. Expand
Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes
TLDR
Assessment of the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Expand
The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS‐CoV‐2 infection
TLDR
A biological background of the potential route for infection of SARS‐CoV‐2 is provided and may enable rapid deciphering male‐related reproductive disorders induced by COVID‐19. Expand
Potential risks of SARS-CoV-2 infection on reproductive health
  • Rong Li, Tailang Yin, +14 authors Jie Qiao
  • Medicine
  • Reproductive BioMedicine Online
  • 2020
TLDR
The potential risks on reproductive health, including reproductive system and function, as well as gamete and embryo development, which was underpinned by the virus, drugs, chemical disinfectants and panic psychology during the outbreak of COVID-19 are focused on. Expand
Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques
TLDR
It is demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2, and the non-human primate model that is established here provides a valuable platform to study Sars-Co V-2 pathogenesis and to evaluate candidate vaccines and therapeutics. Expand
Evaluation of sex‐related hormones and semen characteristics in reproductive‐aged male COVID‐19 patients
TLDR
This study presents an abnormal sex hormone secretion among COVID‐19 patients, suggesting that attention should be paid to reproductive function evaluation in the follow-up, and compared the sex‐related hormone levels between 119 reproductive‐aged men with SARS‐CoV‐2 infection and 273 age‐matched control men. Expand
Pathological Findings in the Testes of COVID-19 Patients: Clinical Implications
TLDR
No evidence of SARS-CoV-2 virus in the testes of deceased COVID-19 patients is found, and these findings can provide evidence-based guidance for donation and inform management strategies to mitigate the risk of testicular injury. Expand
The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city
TLDR
The negativity of SARS-CoV-2 in EPS is found and possibly exclude the sexual transmission of COVID-19. Expand
Human testicular organoid system as a novel tool to study Zika virus pathogenesis
TLDR
The recently developed human testicular organoid (HTO) culture system is composed of SSC, SC, LC, and peritubular cells that maintain >85% viability throughout long-term culture of 23 days, and demonstrated that ZIKV could cross the barrier more efficiently compared to dengue virus without altering barrier permeability. Expand
...
1
2
3
4
5
...