Evaluating the Evidence for Transmission Distortion in Human Pedigrees


Children of a heterozygous parent are expected to carry either allele with equal probability. Exceptions can occur, however, due to meiotic drive, competition among gametes, or viability selection, which we collectively term "transmission distortion" (TD). Although there are several well-characterized examples of these phenomena, their existence in humans… (More)
DOI: 10.1534/genetics.112.139576