• Corpus ID: 30399144

Evaluating the Effect of PIH on Rats-Liver Overloaded with Iron

  title={Evaluating the Effect of PIH on Rats-Liver Overloaded with Iron},
  author={Marwa A A Ibrahim and Alaa-eldin Salah-eldin},
The accumulation of iron (Fe) in the liver is a serious complication of thalassemia and other ironloading anemias requiring long-term blood transfusions. Such patients are directed to suffer death unless they are treated with Fe chelating agents. Desferrioxamine (DFO), deferiprone (L1) and desferasirox (ICL-670) are clinically approved iron chelators used to treat secondary iron overload, but there is still need for new drug candidates due to limited long-term efficacy and drug toxicity… 


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