Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia

@article{Bonnen2006EvaluatingPF,
  title={Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia},
  author={Penelope E. Bonnen and Itsik Pe'er and Robert M. Plenge and Jackie Salit and Jennifer K. Lowe and Michael H. Shapero and Richard P. Lifton and Jan L. Breslow and Mark J. Daly and David E. Reich and Keith W. Jones and Markus Stoffel and David M Altshuler and Jeffrey M. Friedman},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={214-217}
}
Whole-genome association studies are predicted to be especially powerful in isolated populations owing to increased linkage disequilibrium (LD) and decreased allelic diversity, but this possibility has not been empirically tested. We compared genome-wide data on 113,240 SNPs typed on 30 trios from the Pacific island of Kosrae to the same markers typed in the 270 samples from the International HapMap Project. The extent of LD is longer and haplotype diversity is lower in Kosrae than in the… CONTINUE READING

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