Evaluating melanoma drug response and therapeutic escape with quantitative proteomics.

  title={Evaluating melanoma drug response and therapeutic escape with quantitative proteomics.},
  author={Vito W. Rebecca and Elizabeth R. Wood and Inna V. Fedorenko and Kim H. T. Paraiso and Hans Eirik Haarberg and Y. Ann Chen and Yun Xiang and Amod A. Sarnaik and Geoffrey Thomas Gibney and Vernon K. Sondak and John Matthew Koomen and Keiran S. M. Smalley},
  journal={Molecular & cellular proteomics : MCP},
  volume={13 7},
The evolution of cancer therapy into complex regimens with multiple drugs requires novel approaches for the development and evaluation of companion biomarkers. Liquid chromatography-multiple reaction monitoring mass spectrometry (LC-MRM) is a versatile platform for biomarker measurement. In this study, we describe the development and use of the LC-MRM platform to study the adaptive signaling responses of melanoma cells to inhibitors of HSP90 (XL888) and MEK (AZD6244). XL888 had good anti-tumor… CONTINUE READING


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