Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

@inproceedings{Yang2012EvaluatingGP,
  title={Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer},
  author={Lijun Yang and Benjamin T Kress and Harris J Weber and Meenakshisundaram Thiyagarajan and Baozhi Wang and Rashid Deane and Helene Benveniste and Jeffrey J Iliff and Maiken Nedergaard},
  booktitle={Journal of Translational Medicine},
  year={2012}
}
Neurodegenerative diseases such as Alzheimer’s are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brain-wide perivascular pathway along which cerebrospinal fluid (CSF) and interstitial fluid (ISF) rapidly exchange, has recently been identified as a key contributor to the clearance of interstitial solutes from the brain, including amyloid β. These findings suggest that measuring changes in glymphatic… CONTINUE READING
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