Evaluating and modifying Johanson's rolling model to improve its predictability.

@article{Bi2014EvaluatingAM,
  title={Evaluating and modifying Johanson's rolling model to improve its predictability.},
  author={Mingda Bi and Fernando Alvarez-N{\'u}{\~n}ez and Francisco Alvar Alvarez},
  journal={Journal of pharmaceutical sciences},
  year={2014},
  volume={103 7},
  pages={2062-2071}
}
The purpose of this study is to investigate if Johanson's rolling theory can correctly predict the maximum roll surface pressure during the roll compaction. Three model pharmaceutical formulations were roller compacted using the Gerteis Mini Pactor at multiple combinations of roll forces and roll gaps. The resultant ribbon density at each combination of roll force and roll gap was measured and the corresponding maximum roll surface pressure was predicted using Johanson's rolling model. The… CONTINUE READING