Evaluating acute effects of potential reduced-exposure products for smokers: clinical laboratory methodology.

@article{Breland2002EvaluatingAE,
  title={Evaluating acute effects of potential reduced-exposure products for smokers: clinical laboratory methodology.},
  author={Alison B. Breland and August R. Buchhalter and Sarah E. Evans and Thomas E Eissenberg},
  journal={Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco},
  year={2002},
  volume={4 Suppl 2},
  pages={S131-40}
}
Harm reduction for tobacco smokers may involve reducing their exposure to lethal smoke constituents. Assessing smoke constituent exposure and any resulting harm reduction from a potential reduced-exposure product (PREP) will involve preclinical, clinical, and epidemiological research. The purpose of this study was to evaluate a clinical laboratory model for assessing the acute effects of PREPs for smokers. Philip Morris' Accord and R.J. Reynolds' Eclipse were used as examples. Twenty overnight… CONTINUE READING

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