Evaluating GO-based Semantic Similarity Measures

  title={Evaluating GO-based Semantic Similarity Measures},
  author={Catia Pesquita and Daniel Faria and Hugo P. Bastos and Andr{\'e} O. Falc{\~a}o and Francisco M. Couto},
Motivation: While several efforts have been made in measuring GO-based protein semantic similarity, it is still unclear which are the best approaches to measure it and furthermore whether electronic annotations should be used. Results: We studied the behaviour of 8 distinct semantic similarity measures as function of sequence similarity with and without electronic annotations. We found that 5 of these measures shared a cumulative normal distribution pattern, which is likely inherent to the… CONTINUE READING